Synlibris
Transforming the
bioeconomy
We're using high throughput evolution to make protein
manufacturing easy, cheap, and scalable
What would the world look like if we could make any protein for dollars/gram in weeks?
• Even well characterized proteins can cost tens of thousands per gram to manufacture
• Scaling up production of a recombinant protein can take years
• While discovery of new medicines accelerates, ability to produce them lags
• Cheap, easy, production would decrease drug costs, broaden access to critical medicines, and open new therapeutic doors
ORACLE
OrthoRep Assisted
Continuous Library Evolution
Our breakthrough platform utilizing directed evolution of gene libraries to search billions of variants in the volume of a shot glass: applied to protein secretionhttps://www.biorxiv.org/content/10.1101/2025.03.22.644768v2
Mammalian like expression in yeast for easier handling and scaling
High speed evolutionary search at unmatched scale with 1,000,000x genomic error rate
Expression of proteins that are toxic, complex, or hard to fold, unlocking new targets
Parallelizability to 100's of simultaneous optimization campaigns
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